TPD Tox Service

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Get Tox Profiles for your Notifications


We provide toxicological profiles on ingredients for notification purposes through our Tox Service. The profiles are specially prepared by our in-house tox expert for submission in TPD notifications for vape products.


What are the TPD tox requirements?


Article 20.2.c of the TPD requires manufacturers to submit information on the available toxicological data on ingredients. Information to be submitted includes emissions, cardiopulmonary and addictive data on each ingredient.


About the Tox Profiles


Each profile contains the following information:

  • Name and CAS number
  • Available information on (as per TPD requirements):
    • Existence of studies that inform about the chemistry and/or toxicity of emissions.
    • Existence of any studies relating to the carcinogenicity, mutagenicity or toxicity for reproduction of the ingredient.
    • Existence of in vitro and in vivo assays to evaluate the toxicological effects of the ingredient on the heart, blood vessels or respiratory tract
    • Existence of an analysis of the possible addictive properties of the ingredient
    • Existence of any other toxicological data

The profiles are prepared for easy upload to the notification and well-presented for easy assessment by the authority.


Who prepares the profiles?


The profiles are specially prepared for notification purposes by a qualified toxicology expert who has the necessary toxicological experience to write tox profiles on ingredients.


About the Tox Expert


  • Extensive knowledge and experience in toxicology from a career spanning 30 years
  • Worked in a wide range of industries: E-cigarette, pharmaceutical, chemical and agrochemical
  • Performed human health risk assessments and literature reviews on a wide range of chemicals
  • Senior positions held at two major tox research laboratories

His knowledge and experience makes him perfectly placed to prepare TPD compliant tox profiles on ingredients, and advise on other vape-related tox issues.

He is also a UK Home Office Project Licence Holder. Learn more about our expert toxicologist here.


Tried and Tested


The format of the profiles has been used in hundred’s of successful notifications, therefore, we guarantee that our profiles will be accepted for review by the authorities.


Other Tox Services:


In addition to preparing tox profiles to support notifications, our tox expert can perform other important duties, upon request, including:

  • Human health risk assessments on formulations
  • Study summaries and literature reviews on other vape-related safety issues

[/vc_column_text][vc_empty_space height=”15px”][vc_btn title=”Contact us to get started” style=”flat” shape=”square” color=”danger” align=”center” link=”|title:Contact%20Us||”][vc_empty_space][vc_tta_accordion][vc_tta_section title=”How does the Tox Service work?” tab_id=”1509469263265-c013e3eb-8886″][vc_column_text]Step 1. Email your list of ingredient names and corresponding CAS number for which a tox profile is required.

We shall respond to confirm the total price based on the number of profiles and a Paypal link to make your payment (other options are available).

Step 2. Make your payment as per our quote.

You shall receive your profiles by email (PDF documents).[/vc_column_text][/vc_tta_section][vc_tta_section title=”How much does a profile cost?” tab_id=”1509469263207-b57070d4-5d23″][vc_column_text]Each tox profile is £150. Alternatively, you can buy our entire tox database of over 300 common e-liquid ingredients for £995. Click here to learn more[/vc_column_text][/vc_tta_section][vc_tta_section title=”How long will it take to get profiles?” tab_id=”1509469710622-136c62a1-a1e5″][vc_column_text]Tox profiles are available immediately after payment if purchased via the Teachable platform. If we do not have a profile on an ingredient we will create one for you (additional fee may apply). Typically, it takes one or two days to create a new tox profile on an ingredient.[/vc_column_text][/vc_tta_section][vc_tta_section title=”Can you guarantee the profiles will be accepted in the notification?” tab_id=”1509469767403-c88e9b31-0983″][vc_column_text]Yes. The format of the profile has been accepted by European agencies. Please note we do not guarantee the toxicology of an ingredient is accepted by an authority.[/vc_column_text][/vc_tta_section][/vc_tta_accordion][/vc_column][/vc_row]